Articles

Phase contrast microscopy lets scientists see transparent, living cells in detail without staining or harming them. It works by turning […]

Brightfield microscopy isn’t just about powerful objective lenses. The condenser lens actually does a lot of the heavy lifting when

Abbe’s theory of image formation really changed how scientists think about microscopes. He pointed out that clarity in fine details

When light passes through a microscope lens, it just can’t create a perfect image of tiny details. The wave nature

Köhler illumination stands out as a go-to method in optical microscopy because it delivers bright, even lighting across the field

Differential Interference Contrast (DIC) microscopy relies on the physics of polarized light and interference to bring out fine details in

Numerical aperture sits at the core of how well an optical system can show fine details. It tells you how

Optical magnification in a microscope lets you see tiny details by enlarging the image of a specimen with a series

Microscope design really hinges on how we think about light. Ray optics looks at light as straight lines, which makes

Atomic Force Microscopy (AFM) lets us see and measure surfaces at the nanometer scale with a level of precision that

Cryo-electron microscopy (cryo-EM) has really changed the game in structural biology. Scientists can now actually see proteins, viruses, and cellular

Transmission Electron Microscopy (TEM) lets us see structures way beyond what light-based imaging can manage. Instead of visible light, TEM

A scanning electron microscope fires a tightly focused beam of electrons and uses electromagnetic lenses to bring out surface details

Near-field scanning optical microscopy (NSOM), sometimes called scanning near-field optical microscopy (SNOM), lets scientists capture optical details way smaller than

Electron diffraction in a transmission electron microscope (TEM) gives researchers a sharp tool for exploring how atoms line up inside

Quantitative phase microscopy (QPM) gives researchers a precise way to study living cells without needing dyes or stains. It measures

Coherent Anti-Stokes Raman Scattering (CARS) microscopy gives researchers a powerful way to visualize a sample’s chemical makeup without using dyes

Brillouin microscopy gives us a way to see the mechanical landscape of materials without ever touching or changing them. Instead

Digital Holographic Microscopy (DHM) does more than capture the intensity of light—it measures how light waves shift as they pass

Spectral imaging in microscopy isn’t just about snapping a picture. It captures both spatial and spectral information, so every pixel

Raman microscopy brings together the molecular insight of Raman spectroscopy and the spatial detail of optical microscopy. It lets you

Stimulated Emission Depletion (STED) microscopy takes fluorescence imaging to the next level by deciding exactly when and where molecules emit

Interference Reflection Microscopy (IRM) gives researchers a sharp way to see how cells interact with surfaces at the nanometer scale.

Light Sheet Fluorescence Microscopy (LSFM) gives researchers a unique way to capture high-resolution, three-dimensional images with minimal photodamage. By lighting

Total Internal Reflection Fluorescence Microscopy (TIRFM) lets scientists watch what’s happening right at the cell surface with impressive clarity. Using

Structured Illumination Microscopy (SIM) gives researchers a practical way to see beyond the diffraction limit of light, all without ditching

Super-resolution microscopy has totally changed how scientists look at the tiny details inside cells and molecules. Of all the methods

Förster Resonance Energy Transfer (FRET) in microscopy gives us a precise method to study molecular interactions at distances that regular

Scanning tunneling microscopy (STM) changed how we explore surfaces at the atomic scale. It relies on quantum tunneling, where electrons

Magnetic Force Microscopy (MFM) gives us a precise way to visualize and study magnetic domains at the nanoscale. By picking

Scanning Transmission Electron Microscopy (STEM) lets you see and analyze materials right down to the atomic level. It’s kind of